Unveiling the Chemistry of Life, One Discovery at a Time ✝︎ Shared first authorship *Corresponding author Wang lab members 23. Petriti V, Nolan K, Xu W, Tsai S, Wang X, Xie W, Zheng G,* Wang Y,* Ding Y.* Bacterial cytochrome P450 for oxidative halogenated biaryl coupling. ACS Catal. 2025, accepted 22. Traore E, Wang Y, Griffith W, Liu A.* Substrate Analogs Implicate a Free Radical Pathway in Tyrosine Hydroxylase Catalysis. ACS Catal. 2025, 15, 21, 18270–18281 (DOI: 10.1021/acscatal.5c05776) 21. Nolan K,✝︎ Usai R,✝︎ Li B, Jordan S, Wang Y.* Molecular Basis for Peptide Nitration by a Novel Cytochrome P450 Enzyme in RiPP Biosynthesis. ACS Catal. 2025, 15, 12, 10391-10404 (DOI: 10.1021/acscatal.5c01932) 20. Li B, Usai R, Campbell J, Wang Y.* Ligand interactions and small-molecule activation in the pyrrolnitrin biosynthetic enzyme PrnB. J. Biol. Chem. 2025, 301(2),108123 (DOI: 10.1016/j.jbc.2024.108123) 19. Campbell J, Wang Y.* Observing extradiol dioxygenases in action through a crystalline lens. Meth. Enzymol. 2024, 704, 3-25 (DOI: 10.1016/bs.mie.2024.05.020) 18. Nguyen R, Davis I, Dasgupta M, Wang Y, Simon P, Butryn A, Makita H, Bogacz I, Dornevil K, Aller P, Bhowmick A, Chatterjee R, Kim I-S, Zhou T, Mendez D, Paley D, Fuller F, Alonso Mori R, Batyuk A, Sauter N, Brewster A, Orville A, Yachandra V, Yano J, Kern J,* Liu A.* In situ structural observation of a substrate- and peroxide-bound high-spin ferric-hydroperoxo intermediate in P450 enzyme CYP121. J. Am. Chem. Soc., 2023, 145, 46, 25120–25133 (DOI: 10.1021/jacs.3c04991) 17. Jordan S,✝︎ Li B,✝︎ Traore E, Wu Y, Usai R, Liu A, Xie Z-R, Wang Y.* Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis. J. Biol. Chem. 2023, 299(8), 105049 (DOI: 10.1016/j.jbc.2023.105049) 16. Nolan K, Wang Y.* Combined spectroscopic and structural approaches to explore the mechanism of histidine-ligated heme-dependent aromatic oxygenases. Meth. Enzymol. 2023. 685, 405-432 (DOI: 10.1016/bs.mie.2023.03.008) Before joining UGA: 15. Shin I, Wang Y, Liu A.* A new regime of the histidyl-ligated heme-dependent oxygenase superfamily. Proc. Natl. Acad. Sci. U. S. A. 2021, 118(43), e2106561118 (DOI: 10.1073/pnas.2106561118) 14. Wang Y, Shin I, Li J, Liu A.* Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor. J. Biol. Chem. 2021, 297(4), 101176 (DOI: 10.1016/j.jbc.2021.101176) 13. Wang Y, Davis I, Shin I, Xu H, Liu A.* Molecular rationale for partitioning between C-H and C-F bond activation in heme-dependent tyrosine hydroxylase. J. Am. Chem. Soc. 2021, 143(12), 4680-4693 (DOI: 10.1021/jacs.1c00175) 12. Shin I, Davis I, Nieves-Merced K, Wang Y, McHardy S, Liu A.* A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by the spectroscopic and structural study. Chem. Sci. 2021, 12(11), 3984-3998 (DOI: 10.1039/D0SC06369J) 11. Wang Y,✝︎ Liu F,✝︎ Yang Y, Davis I, Liu A.* Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens. Proc. Natl. Acad. Sci. U. S. A. 2020, 117(33), 19720-19730. (DOI: 10.1073/pnas.2005327117) 10. Wang Y, Davis I, Yang Y, Davis I, Chen Y, Naik S, Griffith W, Liu A.* Characterization of the non-heme iron center of cysteamine dioxygenase and its interaction with substrates. J. Biol. Chem. 2020, 295(33), 11789-11802. (DOI: 10.1074/jbc.RA120.013915) 9. Wang Y, Liu A.* Carbon-fluorine bond cleavage mediated by metalloenzymes. Chem. Soc. Rev. 2020, 49, 4906-4925. (DOI: 10.1039/C9CS00740G) 8. Nguyen R, Yang Y, Wang Y, Davis I, Liu A.* Substrate-assisted hydroxylation and O-demethylation in the peroxidase-like cytochrome P450 enzyme CYP121. ACS Catal. 2020, 10(2), 1628-1639. (DOI: 10.1021/acscatal.9b04596) 7. Wang Y, Davis I, Shin I, Wherritt D, Griffith W, Dornevil K, Colabroy K, Liu, A.* Biocatalytic carbon-hydrogen and carbon-fluorine bond cleavage through hydroxylation promoted by a histidyl-ligated heme enzyme. ACS Catal. 2019, 9(6), 4764-4776. (DOI: 10.1021/acscatal.9b00231)Featured by ACS Editors’ Choice and ACS LiveSlides 6. Wang Y, Shin I, Fu Y, Colabroy K, Liu A.* Crystal structures of L-DOPA dioxygenase from Streptomyces Sclerotialus. Biochemistry. 2019, 58(52), 5339-5350. DOI: 10.1021/acs.biochem.9b00396)Invited original contribution for a special issue “Current Topics in Mechanistic Enzymology 2019” 5. Wang Y, Griffith W, Li J, Koto T, Wherritt D, Fritz E, Liu A.* Cofactor biogenesis in cysteamine dioxygenase: C-F bond cleavage with genetically incorporated unnatural tyrosine. Angew. Chem. Int. Ed. 2018, 57(27), 8149-8153. (DOI: 10.1002/ange.201803907) 4. Li J, Griffith W, Davis I, Shin I, Wang J, Li F, Wang Y, Wherritt D, Liu A.* Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase. Nat. Chem. Biol. 2018, 14(9), 853-860. (DOI: 10.1038/s41589-018-0085-5) 3. Wang Y, Li J, Liu A.* Oxygen activation by mononuclear nonheme iron dioxygenases involved in the degradation of aromatics. J. Biol. Inorg. Chem. 2017, 22(2), 395-405. (DOI: 10.1007/s00775-017-1436-5)Invited article for a special issue, “60 Years of Oxygen Activation” 2. Yang Y, Davis I, Ha U, Wang Y, Shin I, Liu A.* A pitcher-and-catcher mechanism drives endogenous substrate isomerization by a dehydrogenase in kynurenine metabolism. J. Biol. Chem. 2016, 291(51), 26252-26261. (DOI: 10.1074/jbc.M116.759712)Featured as "Papers of the Week” 1. Zuo B, Liu Y, Wang L, Zhu Y, Wang Y, Wang X.* Depth profile of the segmental dynamics at a poly(methyl methacrylate) film surface. Soft Matter, 2013,9, 9376-9384. (DOI: 10.1039/C3SM51658J)
